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Short term wear of high Dk soft contact lenses does not alter corneal epithelial cell size or viability

机译:高Dk软性隐形眼镜的短期佩戴不会改变角膜上皮细胞的大小或生存能力

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摘要

BACKGROUND/AIMS—Current contact lenses (CLs) when worn on an extended wear basis cause corneal epithelial alterations. The aim of this study was to evaluate changes in corneal epithelial cell morphology and physiology following short term (3 months) wear of highly oxygen permeable CLs and to compare this with disposable CLs.
METHODS—Subjects were wearers of highly oxygen permeable CLs (n=11, wearing CLs on a 30 night schedule), disposable CL users (n=6, wearing CLs on a 6 night schedule), and non-CL wearers (n=20). Mean CL wear experience was 3 months. Epithelial cells were harvested using corneal cytology and were stained using acridine orange and ethidium bromide. Epithelial cell size and viability were determined.
RESULTS—The majority of epithelial cells recovered were non-viable (71%), and the mean longest cell diameter was 38 (SD 8) µm. Disposable CLs caused an increase in cell size (42 (7) µm) compared with both non-wear (39 (7) µm, p=0.01) and wear of highly oxygen permeable CLs (37 (10) µm, p=0.0049). There was no difference in cell viability between groups.
CONCLUSIONS—Extended wear of disposable CLs caused an 8% increase in cell diameter in harvested corneal epithelial cells following 3 months of CL wear. Cells harvested following 3 months' wear of highly oxygen permeable CLs were indistinguishable from those recovered from non-CL wearers.


机译:背景/目的—当前的隐形眼镜(CL)长时间佩戴后会导致角膜上皮改变。这项研究的目的是评估短期内(3个月)高透氧性CL佩戴后角膜上皮细胞形态和生理的变化,并将其与一次性CL进行比较。方法—受试者是高氧气透过率的CL(n = 11,按30夜计划佩戴CL),一次性CL使用者(n = 6,按6夜的时间表佩戴CL)和非CL的使用者(n = 20) )。平均CL磨损经验为3个月。使用角膜细胞学收集上皮细胞,并使用a啶橙和溴化乙锭染色。确定上皮细胞大小和生存力。结果-回收的大多数上皮细胞不存活(71%),平均最长细胞直径为38(SD 8)μm。与非磨损(39(7)µm,p = 0.01)和高氧气渗透性CL(37(10)µm,p = 0.0049)磨损相比,一次性CL导致细胞尺寸增加(42(7)µm) 。两组之间的细胞生存力没有差异。结论:一次性CL的磨损延长,导致CL磨损3个月后,所收获的角膜上皮细胞的细胞直径增加了8%。戴了3个月的高透氧性CL后收集的细胞与从非CL佩戴者身上回收的细胞没有区别。

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